abstract：:The regulation of growth hormone 1 (GH1) and insulin-like-growth factor-1 (IGF-1) release is under the influence of three pituitary hormones [growth hormone releasing hormone (GHRH), ghrelin (GHRL) and somatostatin (SST)], which act in an autocrine/paracrine fashion in the breast. By binding to their respective recept...

journal_title：Carcinogenesis

authors： Wagner K,Hemminki K,Grzybowska E,Klaes R,Burwinkel B,Bugert P,Schmutzler RK,Wappenschmidt B,Butkiewicz D,Pamula J,Pekala W,Försti A

更新日期：2006-09-01 00:00:00

abstract：:Cell motility is partially dependent on interactions between the integrins and the extracellular matrix. Our previous studies have identified synthetic D-amino acid cell adhesion peptides using a combinatorial screening approach. In this study, we demonstrate that HYD1 (kikmviswkg) completely blocks random haptotactic...

journal_title：Carcinogenesis

authors： Sroka TC,Pennington ME,Cress AE

更新日期：2006-09-01 00:00:00

abstract：:Sulindac, a widely used non-steroidal anti-inflammatory drug (NSAID), has been shown to inhibit chemically induced carcinogenesis in animal models. In the present study, we have investigated the molecular mechanism by which sulindac affects the activity and expression of the enzymes that mediate the initial detoxifica...

journal_title：Carcinogenesis

authors： Ciolino HP,MacDonald CJ,Memon OS,Bass SE,Yeh GC

更新日期：2006-08-01 00:00:00

abstract：:Spices and flavoring plants part rich in supposedly health-promoting phytochemicals are currently receiving much attention as a possible source of cancer chemopreventive compounds. Clove, the sun-dried unopened flower bud from the plant Syzygium aromaticum L. is a commonly used spice and food flavor. In the present wo...

journal_title：Carcinogenesis

authors： Banerjee S,Panda CK,Das S

更新日期：2006-08-01 00:00:00

abstract：:Tamoxifen is a non-steroidal anti-estrogen used for the treatment of breast cancer and, more recently, as a chemopreventive agent in healthy women at high risk of developing breast cancer. On the other hand, tamoxifen is a potent hepatocarcinogen in rats, with both tumor-initiating and tumor-promoting properties. Ther...

journal_title：Carcinogenesis

authors： Tryndyak VP,Muskhelishvili L,Kovalchuk O,Rodriguez-Juarez R,Montgomery B,Churchwell MI,Ross SA,Beland FA,Pogribny IP

更新日期：2006-08-01 00:00:00

abstract：:The anti-cancer efficacy of grape seed extract (GSE) against prostate cancer (PCA) via its anti-proliferative, pro-apoptotic and anti-angiogenic activities in both cell culture and animal models have recently been described by us. GSE is a complex mixture containing gallic acid (GA), catechin (C), epicatechin (EC) and...

journal_title：Carcinogenesis

authors： Veluri R,Singh RP,Liu Z,Thompson JA,Agarwal R,Agarwal C

更新日期：2006-07-01 00:00:00

abstract：:Metastasis-supporting physiological alterations are regulated by cell signaling molecules, which target signal transduction pathways and gene expression. Osteopontin (OPN) overexpression may represent a key molecular event in cancer metastasis. In this study, using metastatic 4T1 and non-metastatic 4T07 murine mammary...

journal_title：Carcinogenesis

authors： Mi Z,Guo H,Wai PY,Gao C,Kuo PC

更新日期：2006-06-01 00:00:00

abstract：:Ataxia-telangiectasia (A-T), which is due to mutations in the ATM gene, is a rare autosomal recessive genomic instability syndrome characterized by radiosensitivity and predisposition to cancer. Epidemiological studies have suggested that relatives of A-T patients (A-T carriers) have increased risks of developing brea...

journal_title：Carcinogenesis

authors： Lu S,Shen K,Wang Y,Santner SJ,Chen J,Brooks SC,Wang YA

更新日期：2006-04-01 00:00:00

abstract：:Salvia miltiorrhiza (SM) has been used clinically in Asian countries to improve the microcirculation in the human body. Salvianolic acid B (Sal B), a pure compound extracted from SM, has been reported to be effective against fibrosis and ischemia-reperfusion injury, possibly through its anti-lipid peroxidation action....

journal_title：Carcinogenesis

authors： Zhou ZT,Yang Y,Ge JP

更新日期：2006-04-01 00:00:00

abstract：:Skin is a major target of carcinogenic trivalent arsenic (arsenite, As3+). It has been thought that cell proliferation is one of the central events involved in the carcinogenic effect of arsenite. Cyclin D1, a nuclear protein playing a pivotal role in cell proliferation and cell cycle transition from G1 to S phases, h...

journal_title：Carcinogenesis

authors： Ouyang W,Li J,Ma Q,Huang C

更新日期：2006-04-01 00:00:00

abstract：:Sulforaphane (SFN), an isothiocyanate first isolated from broccoli, exhibits chemopreventive properties in prostate cancer cells through mechanisms that are poorly understood. We recently reported on a novel mechanism of chemoprotection by SFN in human colon cancer cells, namely the inhibition of histone deacetylase (...

journal_title：Carcinogenesis

authors： Myzak MC,Hardin K,Wang R,Dashwood RH,Ho E

更新日期：2006-04-01 00:00:00

abstract：:Common polymorphisms in genes encoding phase I and phase II enzymes are considered to modify lung cancer risk due to changes in enzyme activity. Candidates include genetic variants of glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and myeloperoxidase (MPO). We performed a large case-control study of these candida...

journal_title：Carcinogenesis

authors： Larsen JE,Colosimo ML,Yang IA,Bowman R,Zimmerman PV,Fong KM

更新日期：2006-03-01 00:00:00

abstract：:3,3'-Diindolylmethane (DIM), an indole derivative produced on consumption of broccoli and other cruciferous vegetables, has been shown to have multiple anticancer effects in both in vivo and in vitro models. The present study was carried out to clarify the mechanism of DIM's antiangiogenic activity. We found that DIM ...

journal_title：Carcinogenesis

authors： Chang X,Firestone GL,Bjeldanes LF

更新日期：2006-03-01 00:00:00

abstract：:EphB2, a receptor tyrosine kinase regulated by the beta-catenin/Tcf4 complex, is expressed in the proliferative compartment of mouse intestine and regulates bidirectional migration of intestinal precursor cells in the crypt-villus axis through repulsive interaction with Ephrin-B ligands. Recently, it has been shown th...

journal_title：Carcinogenesis

authors： Guo DL,Zhang J,Yuen ST,Tsui WY,Chan AS,Ho C,Ji J,Leung SY,Chen X

更新日期：2006-03-01 00:00:00

abstract：:We have shown previously that apoptosis induction by diallyl trisulfide (DATS), a constituent of processed garlic, in PC-3 and DU145 human prostate cancer cells is associated with c-Jun N-terminal kinase and extracellular signal-regulated kinase-mediated phosphorylation of Bcl-2. However, pharmacological inhibition of...

journal_title：Carcinogenesis

authors： Xiao D,Singh SV

更新日期：2006-03-01 00:00:00

abstract：:Despite recent additions to the armory of chemotherapeutic agents for colorectal cancer (CRC) treatment, the results of chemotherapy remain unsatisfactory. 5-Fluorouracil (5-FU) still represents the cornerstone of treatment and resistance to its actions is a major obstacle to successful chemotherapy. Therefore, new ac...

journal_title：Carcinogenesis

authors： Kodach LL,Bos CL,Durán N,Peppelenbosch MP,Ferreira CV,Hardwick JC

更新日期：2006-03-01 00:00:00

abstract：:Nitric oxide donating aspirin (NO-ASA), consisting of a traditional ASA to which a NO-releasing moiety is covalently attached, is a promising chemopreventive agent against colon cancer. Its mechanism of action is not fully delineated. Here we examined its effect on the expression of the nuclear receptor PPARdelta, who...

journal_title：Carcinogenesis

authors： Ouyang N,Williams JL,Rigas B

更新日期：2006-02-01 00:00:00

abstract：:Garcinol, a polyisoprenylated benzophenone, from the fruit rind of Garcinia spp., has been shown to have anti-inflammatory and anticarcinogenic activities. To study its mechanism of action, we analyzed the effects of garcinol and its derivatives, including cambogin, garcim-1 and garcim-2, on arachidonic acid metabolis...

journal_title：Carcinogenesis

authors： Hong J,Sang S,Park HJ,Kwon SJ,Suh N,Huang MT,Ho CT,Yang CS

更新日期：2006-02-01 00:00:00

abstract：:We studied the modulating effects of caffeic acid and chlorogenic acid (two common coffee polyphenols) on the in vitro methylation of synthetic DNA substrates and also on the methylation status of the promoter region of a representative gene in two human cancer cells lines. Under conditions that were suitable for the ...

journal_title：Carcinogenesis

authors： Lee WJ,Zhu BT

更新日期：2006-02-01 00:00:00

abstract：:Overexpression of the helix-loop-helix protein Id-1 has been reported in over 20 types of cancer. While a number of factors have been demonstrated to regulate Id-1 gene transcription, little is known about the mechanisms responsible for its degradation. In this study, we have demonstrated that Id-1 protein stability w...

journal_title：Carcinogenesis

authors： Ling MT,Kwok WK,Fung MK,Xianghong W,Wong YC

更新日期：2006-02-01 00:00:00

abstract：:The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteer...

journal_title：Carcinogenesis

authors： Someya M,Sakata K,Matsumoto Y,Yamamoto H,Monobe M,Ikeda H,Ando K,Hosoi Y,Suzuki N,Hareyama M

更新日期：2006-01-01 00:00:00

abstract：:We have recently shown that the prostaglandin E(2) (PGE(2)) receptor EP(3) plays an important role in suppression of colon cancer cell proliferation and that its deficiency enhances late stage colon carcinogenesis. Here we examined the effects of EP(3)-deficiency on two-stage skin carcinogenesis. 7,12-Dimethylbenz[a]a...

journal_title：Carcinogenesis

authors： Shoji Y,Takahashi M,Takasuka N,Niho N,Kitamura T,Sato H,Maruyama T,Sugimoto Y,Narumiya S,Sugimura T,Wakabayashi K

更新日期：2005-12-01 00:00:00

abstract：:The aim of this study was to investigate selected proteomic markers of the metabolic phenotype of breast carcinomas as prognostic markers of cancer progression. For this purpose, a series of 101 breast carcinomas and 13 uninvolved breast samples were examined for quantitative differences in protein expression of mitoc...

journal_title：Carcinogenesis

authors： Isidoro A,Casado E,Redondo A,Acebo P,Espinosa E,Alonso AM,Cejas P,Hardisson D,Fresno Vara JA,Belda-Iniesta C,González-Barón M,Cuezva JM

更新日期：2005-12-01 00:00:00

abstract：:Telomerase activity is observed in approximately 90% of human cancer including esophageal squamous cell cancer. Normal somatic cells do not display telomerase activity on a regular basis. The major mechanism to regulate telomerase activity in human cells is the transcriptional control of the catalytic subunit, the hum...

journal_title：Carcinogenesis

authors： Quante M,Heeg S,von Werder A,Goessel G,Fulda C,Doebele M,Nakagawa H,Beijersbergen R,Blum HE,Opitz OG

更新日期：2005-11-01 00:00:00

abstract：:Chemopreventive activities of all-trans retinoic acid (AtRA), 9-cis retinoic acid (9cRA), retinol (ROL) and beta-carotene (betaC) were evaluated during hepatocarcinogenesis. Rats received 1 mg/100 g body wt AtRA (AtRA group), 9cRA (9cRA group), ROL (ROL group), 7 mg/100 g body wt betaC (betaC group) or corn oil (CO gr...

journal_title：Carcinogenesis

authors： de Almeida Vasconcelos Fonseca EM,Chagas CE,Mazzantini RP,Heidor R,Ong TP,Moreno FS

更新日期：2005-11-01 00:00:00

abstract：:Functional activation of beta-catenin/Tcf signaling plays an important role in the early events in colorectal carcinogenesis. We examined the effect of ionomycin against beta-catenin/Tcf signaling in colon cancer cells. Reporter gene assay showed that ionomycin inhibited beta-catenin/Tcf signaling efficiently. In addi...

journal_title：Carcinogenesis

authors： Park CH,Hahm ER,Lee JH,Jung KC,Rhee HS,Yang CH

更新日期：2005-11-01 00:00:00

abstract：:Individuals carrying germline mutations in one allele of the BRCA1 or BRCA2 genes are at significantly increased risk of developing cancer. Although the increased risk of breast cancer is often highlighted, cancer at several other sites is also considerably more common in these individuals. Here, we discuss existing k...

journal_title：Carcinogenesis

authors： Sowter HM,Ashworth A

更新日期：2005-10-01 00:00:00

abstract：:The hedgehog pathway plays a critical role in the development of the foregut. Recent studies indicate that the hedgehog pathway activation occurs in the stomach and other gastrointestinal cancers. However, the association of hedgehog pathway activation with tumor stage, differentiation and tumor subtype is not well do...

journal_title：Carcinogenesis

authors： Ma X,Chen K,Huang S,Zhang X,Adegboyega PA,Evers BM,Zhang H,Xie J

更新日期：2005-10-01 00:00:00

abstract：:To test the hypothesis that aberrations of DNA repair contribute to susceptibility for the progression of gastroesophageal reflux disease (GERD) into Barrett esophagus (BE) and esophageal adenocarcinoma (EADC), we studied the frequency of polymorphisms of selected DNA repair genes in patients with GERD (n = 126), BE (...

journal_title：Carcinogenesis

authors： Casson AG,Zheng Z,Evans SC,Veugelers PJ,Porter GA,Guernsey DL

更新日期：2005-09-01 00:00:00

abstract：:Recent studies have revealed that 1,2,3,4,6-penta-O-galloyl-beta-d-glucose (PGG) has anti-tumorigenic activity in vitro. In the present work, we evaluated the in vitro and in vivo antiangiogenic and antitumor activities of PGG and examined its molecular mechanisms. PGG significantly inhibited the proliferation and tub...

journal_title：Carcinogenesis

authors： Huh JE,Lee EO,Kim MS,Kang KS,Kim CH,Cha BC,Surh YJ,Kim SH

更新日期：2005-08-01 00:00:00

abstract：:It is estimated that one-third of Americans use dietary herbal supplements on a regular basis. Diets rich in bioactive phytochemicals are associated with reduced risk of certain cancers, notably, colon cancer. Herbal supplements have not been directly tested as sources of bioactive cancer preventives. Hence, this stud...

journal_title：Carcinogenesis

authors： Volate SR,Davenport DM,Muga SJ,Wargovich MJ

更新日期：2005-08-01 00:00:00

abstract：:Apolipoprotein E (apoE) plays a major role in the metabolism of bile acids, cholesterol and triglycerides, and has recently been proposed as being involved in the carcinogenic process. Given the potential role of bile acids in colorectal cancer etiology, it is reasonable that colorectal cancer risk might be modified b...

journal_title：Carcinogenesis

authors： Slattery ML,Sweeney C,Murtaugh M,Ma KN,Potter JD,Levin TR,Samowitz W,Wolff R

更新日期：2005-08-01 00:00:00

abstract：:Recent studies have suggested that the straightforward role of p53 as a transcription factor that functions by inducing apoptotic target genes to eliminate developing tumor cells is only part of a much more complicated story. There is now a firm body of evidence supporting a transcriptionally independent activity of p...

journal_title：Carcinogenesis

authors： Yee KS,Vousden KH

更新日期：2005-08-01 00:00:00

abstract：:Most cancer cells show resistance to ionizing radiation (IR)-induced cell death. Recently, Ki-Ras was reported to be responsible for the increased radioresistance. We report here that inhibition of IR-induced activaton of nuclear transcription factor kappa B (NF-kappaB) but not of either Akt or MAPK kinase (MEK), incr...

journal_title：Carcinogenesis

authors： Kim BY,Kim KA,Kwon O,Kim SO,Kim MS,Kim BS,Oh WK,Kim GD,Jung M,Ahn JS

更新日期：2005-08-01 00:00:00

abstract：:Lack of functional telomeres can cause chromosomal aberrations. This type of genetic instability may promote tumorigenesis. We have investigated the association between mean telomere length in buccal cells (assessed with quantitative real-time PCR) and bladder cancer risk in a case-control study. Patients with bladder...

journal_title：Carcinogenesis

authors： Broberg K,Björk J,Paulsson K,Höglund M,Albin M

更新日期：2005-07-01 00:00:00

abstract：:Long-Evans Cinnamon (LEC) rats, a model for human Wilson's disease, develop chronic hepatitis and liver tumors owing to accumulation of copper and induced oxidative stress. Lipid peroxidation (LPO)-induced etheno-DNA adducts in nuclear- and mitochondrial-DNA along with apoptosis was measured in LEC rat liver. Levels o...

journal_title：Carcinogenesis

authors： Nair J,Strand S,Frank N,Knauft J,Wesch H,Galle PR,Bartsch H

更新日期：2005-07-01 00:00:00

abstract：:Plant chlorophylls and carotenoids are highly colored, conjugated polyenes that play central roles in photosynthesis. Other porphyrins (tetrapyrroles), such as cytochromes, which are structurally related to chlorophyll, participate in redox reactions in many living systems. An unexpected new property of tetrapyrroles,...

journal_title：Carcinogenesis

authors： Fahey JW,Stephenson KK,Dinkova-Kostova AT,Egner PA,Kensler TW,Talalay P

更新日期：2005-07-01 00:00:00

abstract：:Genetically modified mice with overexpressed and/or deleted genes have been used extensively to model human cancer. However, it is uncertain as to what extent the mouse models reproduce the corresponding cancers in humans. We have compared the global gene expression patterns in human and mouse hepatocellular carcinoma...

journal_title：Carcinogenesis

authors： Lee JS,Grisham JW,Thorgeirsson SS

更新日期：2005-06-01 00:00:00

abstract：:Abnormalities in the expression of DMBT1 (deleted in malignant brain tumors 1) have been implicated in the development of esophageal, gastric and colorectal cancers of the alimentary tract, but the underlying mechanism remains unclear. In the present study, using the gastric cell line AGS, we identified two intracellu...

journal_title：Carcinogenesis

authors： Kang W,Nielsen O,Fenger C,Leslie G,Holmskov U,Reid KB

更新日期：2005-06-01 00:00:00

abstract：:Telomere dynamics are a critical component of both aging and cancer. Telomeres progressively shorten in almost all dividing cells and most human cells do not express or maintain sufficient telomerase activity to fully maintain telomeres. There is accumulating evidence that when only a few telomeres are short, they for...

journal_title：Carcinogenesis

authors： Shay JW,Wright WE

更新日期：2005-05-01 00:00:00